Antibodies to Self-Antigens Predispose to Primary Lung Allograft Dysfunction and Chronic Rejection

Presence of antibodies to self-antigens pretransplant increases the risk of PGD immediately after transplant period and BOS on long-term follow-up. Primary graft dysfunction is associated with an inflammatory cascade that augments the alloimmune (anti-HLA) response that predisposes to BOS.