Response of Brain Oxygenation and Metabolism to Deep Hypothermic Circulatory Arrest in Newborn Piglets: Comparison of pH-Stat and Alpha-Stat Strategies

The increase in p-CREB, p-Akt, Bcl-2, Bcl-2/Bax, and delay in increase of dopamine indicated that pH-stat, in the piglet model, prolongs “safe” time of DHCA and provides some brain protection against ischemic injury.