کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2887362 1574235 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is Thromboangiitis Obliterans Presentation Influenced by Cannabis Addiction?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Is Thromboangiitis Obliterans Presentation Influenced by Cannabis Addiction?
چکیده انگلیسی

BackgroundCannabis implication in the pathophysiology of distal arteritis remains controversial. The aim is to assess whether cannabis co-exposure influences presentation and outcome of thromboangiitis obliterans (TAO) in tobacco smokers.MethodsAll consecutive patients presenting with a definite TAO were retrospectively reviewed according to their tobacco and cannabis consumption status.ResultsA total of 38 patients with a definite TAO were included in this study. In all, 10 patients (26%) used tobacco together with cannabis (δ9-trans-tetrahydrocannabinol [THC], THC+), whereas 28 patients (74%) were only tobacco smokers (THC−). Tobacco exposure was comparable in both groups (21.7 ± 12 vs. 26.7 ± 17 pack-years). THC+ patients were younger than THC− patients at onset of symptoms (28.5 ± 7 years vs. 36.6 ± 10.5 years, p = 0.02) and have more frequently unilateral involvement of lower limbs (44% vs. 7%, p = 0.02). Although 66% of patients presented with critical ischemia of lower limbs, THC+ patients exhibited more often rest pain without ischemic ulcers (50% vs. 5%, p = 0.048). Upper limbs were clinically affected in 50% of THC+ patients and 32% of THC− patients. Repeated infusions of iloprost were required in 84% of patients. Outcome and rate of minor and major amputations (10%) did not differ between groups.ConclusionCannabis exposure influences the age at onset and presentation of TAO, but not the outcome. The data of present study suggest that cannabis represent a co-factor of tobacco that may accelerate TAO onset and presentation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Vascular Surgery - Volume 25, Issue 4, May 2011, Pages 469–473
نویسندگان
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