Young Environment Reverses the Declined Activity of Aged Rat-Derived Endothelial Progenitor Cells: Involvement of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

A young environment partly restores the declined AEPC activity and promotes AEPC homing to vascular injury sites; activation of the PI3-K/Akt signaling pathway is at least partly responsible for this process.