کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2887929 1574241 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Shock Wave-Pretreated Bone Marrow Cells Further Improve Left Ventricular Function After Myocardial Infarction in Rabbits
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Shock Wave-Pretreated Bone Marrow Cells Further Improve Left Ventricular Function After Myocardial Infarction in Rabbits
چکیده انگلیسی

BackgroundWe tested whether shock wave (SW) offers additional benefits in improving left ventricular (LV) function after acute myocardial infarction (AMI) in rabbits receiving SW-treated autologous bone marrow-derived mononuclear cells (BMDMNCs) transplantation.Methods and ResultsSaline (750 μL; group 2), BMDMNCs (1.0 × 107; group 3), or preimplant SW-treated BMDMNCs (group 4) were implanted into the infarct area of male rabbits 15 minutes after left coronary artery ligation, whereas eight rabbits without AMI served as controls (group 1; n = 8 per group). The results showed that in infarct area of LV, protein expressions of Cx43 and cytochrome C in mitochondria and endothelial nitric oxide synthase mRNA expression were lower in group 2 than in other groups, and decreased in group 3 as compared with groups 1 and 4 (all p values < 0.01). Conversely, mRNA expressions of endothelin-1 and matrix metalloproteinase-9, mitochondrial oxidative stress, and total fibrotic area were higher in group 2 than in other groups (all p values < 0.05). Furthermore, 6-month LV function by 2-D echo/angiogram showed significant impairment in group 2 than in other groups and in group 3 than in groups 1 and 4 (all p values < 0.005).ConclusionsApplication of SW-treated autologous BMDMNCs is superior to BMDMNCs alone for preserving LV function after AMI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Vascular Surgery - Volume 24, Issue 6, August 2010, Pages 809–821
نویسندگان
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