کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2903563 1173394 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sleep-Disordered Breathing, Obesity, and Airway Inflammation in Children and Adolescents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Sleep-Disordered Breathing, Obesity, and Airway Inflammation in Children and Adolescents
چکیده انگلیسی

BackgroundTo investigate the relationship between obstructive sleep apnea syndrome (OSAS) and exhaled nitric oxide (eNO) in overweight children and adolescents without asthma or atopy and to assess whether obesity per se is associated with increased airway inflammation.MethodsConsecutive overweight subjects without symptoms of asthma or allergy were recruited at a pediatric obesity clinic. A normal-weight control group without OSAS and asthma or allergy was also recruited. All subjects underwent polysomnography and two measurements of eNO (afternoon and morning after polysomnography).ResultsControlling for age, the mean (± SD) afternoon eNO concentration was significantly higher in the snoring group (14.1 ± 1.1 parts per billion [ppb]) compared with the normal-weight group (10.1 ± 0.8 ppb; p = 0.03) and with the overweight group with normal polysomnography findings (8.9 ± 0.8 ppb; p = 0.007). The afternoon eNO concentration was also different between the OSAS group (11.9 ± 1.0 ppb) and the overweight group with normal polysomnography findings (p = 0.03). Morning eNO values were higher in the OSAS group (12.3 ± 1.1 ppb) than in the normal weight group (9.9 ± 0.8 ppb; p = 0.047) and in the overweight control group (9.7 ± 0.7 ppb; p = 0.02). BMI z score was not significantly correlated with afternoon eNO concentration or with morning eNO concentration.ConclusionThis study illustrates that both habitual snoring and OSAS are associated with increased airway inflammation in overweight children as assessed by higher eNO levels. Furthermore, it was demonstrated that childhood obesity in the absence of sleep-disordered breathing is not associated with increased airway inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 134, Issue 6, December 2008, Pages 1169–1175
نویسندگان
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