کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2904211 1173406 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic Significance of Thin-Section CT Scan Findings in Small-Sized Lung Adenocarcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Prognostic Significance of Thin-Section CT Scan Findings in Small-Sized Lung Adenocarcinoma
چکیده انگلیسی

ObjectivesThe purpose of this study is to evaluate the prognostic importance of thin-section (TS) CT scan findings in small-sized lung adenocarcinomas.Patients and methodsWe reviewed TS-CT scan findings and pathologic specimens from 359 consecutive patients who underwent surgical resection for peripheral lung adenocarcinomas ≤ 20 mm in diameter during the period from July 1997 to May 2006. By using TS-CT scan images, tumors were defined as air-containing types if the maximum diameter of tumor opacity on mediastinal window images was less than or equal to half of that seen on lung window images, and as a solid-density type if the maximum diameter on the mediastinal window images was more than half of that on lung window images. We compared TS-CT scan findings to pathologic findings (ie, lymph node metastasis, pleural invasion, vessel invasion, and lymphatic invasion) and prognosis. The following prognostic factors were analyzed by χ2 test and Cox proportional hazard model: age; gender; tumor size; pathologic stage; TS-CT scan findings; histologic subtypes defined by Noguchi et al (ie, Noguchi type); pleural involvement; lymphatic invasion; and vascular invasion.ResultsNo pathologic invasive findings or recurrence were found in patients with air-containing-type tumors. Pathologic invasive findings and recurrence were found in 10 to 30% of patients with solid-density-type tumors. The air-containing type tumors seen on TS-CT scans and Noguchi type A or B tumors were demonstrated as prognostic factors for good outcome by χ2 test (p < 0.001). Multivariate analyses revealed lymphatic permeation as a significant prognostic factor.ConclusionThe TS-CT scan findings were important predictive factors for postsurgical outcome in patients with lung adenocarcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 133, Issue 2, February 2008, Pages 441–447
نویسندگان
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