Visceral Adiposity Index and pattern of dyslipidaemia at different stages of glucose intolerance—A study from India

AimTo see the pattern of dyslipidaemia and Visceral Adiposity Index (VAI) at different stages of glucose intolerance in Indian population.MethodsData of 600 subjects were considered for this analysis. Waist circumference and BMI were recorded. OGTT and lipid profile were done. Subjects were divided into three groups; Group 1 (Normoglycaemic), Group 2 (Prediabetes) and Group 3 (new DM). Subjects having one or more lipid parameters outside the targets recommended by ADA were considered to have dyslipidaemia. VAI, a sex-specific index, was calculated.ResultsLDL-C was the most common isolated single abnormality (84.5%), followed by HDL-C (58.7%) and triglycerides (49.7%) among the total subjects. 73% had high LDL-C and 56% had low HDL-C even in normoglycaemic subjects. LDL-C abnormality was similar in prediabetes and diabetes. Commonest combination of two abnormalities was seen mainly with LDL-C and HDL-C. Mean VAI increased at different stages of glucose intolerance and VAI ≥ 2.3 gave sensitivity of 61.2% and specificity of 59.7% to detect glucose intolerance.ConclusionsThe most common single lipid abnormality was high LDL-C. Combination of two abnormalities was seen with LDL-C and HDL-C. VAI increased at different stages of glucose intolerance. These findings may be useful for targeting high-risk population.