Association between the leptin receptor gene polymorphism and lipoprotein profile in Chinese type 2 diabetes

The LEPR G3057A mutation was common in the Chinese population, this polymorphism was not associated with the glucose metabolic parameters and plasma leptin levels in Chinese subjects, but positively associated with plasma TG and LDL-C levels, negatively associated with plasma HDL-C levels in Chinese diabetic patients. It may contribute to the onset of type 2 diabetes by regulating lipid metabolism and affecting the distribution of local body mass.