Weak linkage in insulin receptor: Identification of mutation prone point

SummaryMutation within insulin receptor (IR) can be seen. About 50 cases of insulin receptor abnormality were reported. Presently, prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. To identify the point vulnerable to mutate is a new trend to expand the knowledge on disorders in genomic and proteomic level of diseases.MethodsHere, the author performed a bioinformatics analysis to study the determine positions that tend to comply peptide motifs in the amino acid sequence of IR. To identify the weak linkage in IR, a new bioinformatics tool namely GlobPlot was used.ResultsAccording to this work, the positions 140-158 are identified as the position resist to mutation.ConclusionBased on this study, the weak linkages in the IR can be identified and can be good information for the prediction of possible new mutations that can result in phenotype abnormality. In addition, the results from this study can be good information for further research on the diagnosis for IR abnormalities and new treatment.