کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2912097 1575466 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Hospital Discharge Risk Score for 1-Year All-cause Mortality or Non-fatal Cardiovascular Events in Patients with Lower-extremity Peripheral Artery Disease, with and without Revascularisation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
A Hospital Discharge Risk Score for 1-Year All-cause Mortality or Non-fatal Cardiovascular Events in Patients with Lower-extremity Peripheral Artery Disease, with and without Revascularisation
چکیده انگلیسی

ObjectivesThis study aims to determine a hospital discharge prognostic risk score for patients with lower-extremity peripheral artery disease (PAD) with and without revascularisation.Design, materials and methodsA prognostic score on mortality or non-fatal cardiovascular events was determined using the database of a multicentre prospective study enrolling consecutive patients hospitalised for PAD (COhorte de Patients ARTeriopathes, COPART).ResultsWe analysed the data of 640 patients in the derivation cohort and 517 in the validation cohort. The risk score (and corresponding points) included the following factors: age 75–84 years (+2), ≥85 years (+3); previous myocardial infarction (+1); creatinine clearance: ≤30 ml min−1 1.73 m−2 (+1.5), 0.30–0.59 (+1), ankle–brachial index: <0.3 (+2), 0.3–0.49 (+1.5) and >1.3 (+2); C-reactive protein (CRP) ≥70 mg l−1 (+2); and association of statins, anti-platelet agents and renin–angiotensin system inhibitors (−1.5). The frequency of the composite outcome increased significantly with the predicted risk: low risk (≤0 point), 2%; medium (0.5–2 points), 12.8%; high (2.5–4 points), 23%; very high (≥4.5 points): 42.2%. The model had a good performance in terms of discrimination (C-statistic 0.74 and 0.76) and calibration (Hosmer–Lemeshow 0.65).ConclusionsWe propose the validated COPART risk score for hospitalised severe PAD. This prognostic risk score is based on six variables easily identifiable in clinical practice. Our study highlights the favourable prognostic impact of the prescription at discharge of combined drug therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 45, Issue 5, May 2013, Pages 488–496
نویسندگان
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