کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2913715 1575482 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Venous Angioplasty in Patients with Multiple Sclerosis: Results of a Pilot Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Venous Angioplasty in Patients with Multiple Sclerosis: Results of a Pilot Study
چکیده انگلیسی

ObjectivesChronic cerebrospinal venous insufficiency (CCSVI) is associated with multiple sclerosis (MS). The objective of the study was to see if percutaneous transluminal angioplasty (PTA) of duplex-detected lesions, of the internal jugular and/or azygous veins, was safe, burdened by a significant restenosis rate, and whether there was any evidence that treatment reduced MS disease activity.Design: This was a case-control study.Materials: We studied 15 patients with relapsing–remitting MS and duplex-detected CCSVI.MethodsEight patients had PTA in addition to medical therapy (immediate treatment group (ITG)), whereas seven had treatment with PTA after 6 months of medical therapy alone (delayed treatment group (DTG)).ResultsNo adverse events occurred. At 1 year, there was a restenosis rate of 27%. Overall, PTA was followed by a significant improvement in functional score compared with baseline (p < 0.02). The annualised relapse rate was 0.12% in the ITG compared with 0.66% in the DTG (p = NS). Magnetic resonance imaging (MRI) blindly demonstrates a trend for fewer T2 lesions in the ITG (p = 0.081), corresponding to a 10% decrease in the ITG compared with a 23% increase in the DTG over the first 6 months of the study.ConclusionsThis study further confirms the safety of PTA treatment in patients with CCSVI associated with MS. The results, despite the significant rate of restenosis, are encouraging and warrant a larger multicentre double-blinded, randomised study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 43, Issue 1, January 2012, Pages 116–122
نویسندگان
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