کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2914187 | 1575537 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The Neurological Morbidity of Carotid Revascularisation: Using Markers of Cellular Brain Injury to Compare CEA and CAS The Neurological Morbidity of Carotid Revascularisation: Using Markers of Cellular Brain Injury to Compare CEA and CAS](/preview/png/2914187.png)
AimThis comparative study attempts to evaluate the profile of S-100β and Neuron-Specific Enolase (NSE), biomarkers of brain injury, in patients undergoing carotid endarterectomy (CEA) and carotid artery stenting (CAS) and to correlate this with haemodynamic and embolic events detected using trans-cranial Doppler (TCD).Methods52 patients with internal carotid artery stenosis requiring intervention were recruited. 24 patients underwent CAS, and 28 underwent CEA. TCD was performed peri-operatively to record mean Middle Cerebral Artery (MCA) velocity and number of High Intensity Transient Signals (HITS) in the MCA of the operated side. Serum was drawn pre-operatively and at six time points in a 48 hour post-operative period, and then assayed using automated commercial equipment. Within and between group variability in markers were assessed by Generalized Estimation Equations modelling.ResultsCAS caused more HITS (p = 0.028) but less haemodynamic disturbance (p = 0.0001) than CEA. Treatment modality (CAS versus CEA) had no direct effect on S-100 changes (p = 0.467). NSE levels declined after revascularisation in the CAS group but not after CEA (p = 0.002). S-100β levels rose in patients who had higher numbers of HITS (p = 0.002). S-100β and NSE were not associated with changes in MCA velocity (p > 0.5). S-100β alone increased significantly at 24 hours in those patients with a post-operative neurological deficit (p = 0.015).ConclusionsTrans-cranial Doppler findings suggest that the mechanisms of rise in S-100β and NSE levels may differ and may be due to increased peri-operative micro-embolisation and cerebral hypoperfusion respectively. Further studies are required to assess the clinical significance of these observed changes.
Journal: European Journal of Vascular and Endovascular Surgery - Volume 34, Issue 5, November 2007, Pages 552–560