کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2915123 1575557 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Combined Effect of Iloprost and N-Acetylcysteine in Preventing Spinal Cord Ischemia in Rabbits
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The Combined Effect of Iloprost and N-Acetylcysteine in Preventing Spinal Cord Ischemia in Rabbits
چکیده انگلیسی

ObjectivesThis study investigated the cytoprotective effects of N-acetylcysteine (NAC) and iloprost on spinal cord ischemia in an experimental model.Materials and methodsThirty-five (male) New Zealand white rabbits were included in five study groups (n=7, each group). One group served as Sham. Rabbits in other groups had their abdominal aorta cross-clamped just above the iliac bifurcation for 40 min. During aortic cross clamping, iloprost, NAC, both iloprost and NAC or saline (control) were infused.ResultsIn NAC, iloprost, and iloprost+NAC groups, neurological status of rabbits (Tarlov score) 24 and 48 h after the operation was better than the control group (p<0.01), but worse than the Sham group (p<0.01). There was minimal neuronal damage in the iloprost treated groups compared to the NAC group (p<0.05). Mean viability index values in NAC, iloprost and iloprost+NAC groups were higher than the control group (p<0.01). Viability index in the NAC group was lower than the iloprost and iloprost+NAC groups.ConclusionsThe use of iloprost and NAC may provide better protection from spinal cord ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 31, Issue 4, April 2006, Pages 366–372
نویسندگان
, , , , , , , ,