کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2917068 1175655 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular Matrix Biomarker, Fibulin-1 and Its Association with Soluble uPAR in a Bi-ethnic South African Population: The SAfrEIC Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Extracellular Matrix Biomarker, Fibulin-1 and Its Association with Soluble uPAR in a Bi-ethnic South African Population: The SAfrEIC Study
چکیده انگلیسی

BackgroundFibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate inflammatory processes associated with extracellular matrix turnover in atherosclerosis. We explored the independent relationship of fibulin-1 with these inflammatory markers in a bi-ethnic South African population.MethodsThis study included 290 Africans (men: n = 130 and women: n = 160) and 343 sex- and age-matched Caucasians (men: n = 160 and women: n = 183). Serum fibulin-1, suPAR, CRP and albumin levels were measured along with conventional cardiovascular and metabolic variables.ResultsIn both single and age-adjusted regression analyses, fibulin-1 correlated with both suPAR and albumin in African men and with suPAR in Caucasian men. These findings were absent in women. In multivariate regression analysis, these associations were confirmed in African men (R2 = 0.22; β=0.329; p < 0.001) and Caucasian men (R2 = 0.14; β=0.234; p = 0.008). Fibulin-1 independently associated positively with suPAR in all men, but inversely with albumin in African men only.ConclusionsThese results are indicating the presence of potential subclinical inflammation (suPAR) within the extracellular matrix of endothelial tissue, contributing to the potential onset of cardiac fibrosis or vascular sclerosis among these South African men with lower albumin levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart, Lung and Circulation - Volume 24, Issue 3, March 2015, Pages 298–305
نویسندگان
, , , , , ,