کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2918219 1175688 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Left Ventricular Mass is Preserved in Patients with Idiopathic Pulmonary Arterial Hypertension and Eisenmenger's Syndrome
ترجمه فارسی عنوان
توده بطنی چپ در بیماران مبتلا به فشارخون شریان ریه ایدیوپاتیک و سندرم آیزنمجر محافظت می شود
کلمات کلیدی
هیپرتروفی بطنی چپ، رزونانس مغناطیسی قلب و عروق، حجم بطن چپ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundLeft ventricular (LV) atrophic remodelling was described for chronic thromboembolic pulmonary hypertension (PH) but not in other forms of PH. We aimed to assess LV morphometric changes in idiopathic pulmonary arterial hypertension (IPAH) and Eisenmenger's syndrome(ES).MethodsFifteen patients with IPAH, 15 patients with ES and 15 healthy volunteers were included. Magnetic resonance was used to measure masses of LV, interventricular septum (IVS), LV free wall (LVFW), and LV end diastolic volume (LVEDV) indexed for body surface area.ResultsBetween patients with IPAH, ES and controls no differences in LVmassindex (54.4[45.2-63.3] vs 58.7[41.5-106.1] vs 52.8[46.5-59.3], p = 0.50), IVSmassindex (21.6[18.2-21.9)] vs 27.4[18.0-32.9] vs 20.7[18.2-23.2], p = 0.18), and LVFWmassindex ([32.4[27.1-40.0] vs 36.7[30.9-62.1] vs 32.5[26.9-36.1], p = 0.29) were found. LVEDVindex was lower in IPAH patients than in controls and in ES patients (54.9[46.9-58.5] vs 75.2[62.4-88.9] vs 73.5[62.1-77.5], p < 0.001). In IPAH LVEDV but not LV mass correlated with pulmonary vascular resistance (r = -0.56, p = 0.03) and cardiac output (r = 0.59, p = 0.02).ConclusionsLV mass is not reduced in patients with IPAH and with ES and is not affected by haemodynamic severity of PH. LVEDV is reduced in IPAH patients in proportion to reduced pulmonary flow but preserved in patients with ES, where reduced pulmonary flow to LV is compensated by right-to left shunt.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart, Lung and Circulation - Volume 23, Issue 5, May 2014, Pages 454–461
نویسندگان
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