کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2919220 1175708 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in Exercise Capacity and Cardiac Performance in a Series of Patients with Eisenmenger's Syndrome Transitioned from Selective to Dual Endothelin Receptor Antagonist
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Changes in Exercise Capacity and Cardiac Performance in a Series of Patients with Eisenmenger's Syndrome Transitioned from Selective to Dual Endothelin Receptor Antagonist
چکیده انگلیسی

BackgroundDifferences in clinical effects between selective and dual endothelin (ET) receptor antagonists (ERA) in patients with pulmonary arterial hypertension (PAH) are currently unknown. We aimed to assess prospectively how transition from selective (sitaxsentan) to dual (bosentan) ERA affected exercise capacity and cardiocirculatory performance in patients with Eisenmenger's syndrome.MethodsA series of seven stable patients with Eisenmenger's syndrome aged 40.0 (30.0–56.0) years old treated with sitaxsentan were assessed before and three months after transition to bosentan. Six minute walk test and magnetic resonance to assess LV and RV mass, volume and ejection fraction, and pulmonary flow, and laboratory tests were performed.ResultsWe observed an increase in LV mass [96.5 (66.0–116.0) vs. 123.0 (93.0–146.0) g; p = 0.03], LV ejection fraction [55.0 (44.0–63.0) vs. 65.0 (58.0–70.0)%; p = 0.02)], and pulmonary flow [64 (53.0–71.0) vs. 69.0 (55.0–84.0) ml/beat; p = 0.046]. This was accompanied by an increase of oxygen saturation, elongation of 6MWD [435.0 (378.0–482.3) vs. 474 (405.0–534.7); p = 0.02], decrease of NTproBNP level and increase of ET-1 level.ConclusionsThree month follow-up of stable patients with Eisenmenger's syndrome transitioned from sitaxsentan to bosentan revealed improvement of exercise capacity despite significant elevation of ET-1 level. Concurrent increase of LV ejection fraction and pulmonary flow might have contributed to these favourable effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart, Lung and Circulation - Volume 21, Issue 11, November 2012, Pages 671–678
نویسندگان
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