کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2924121 1175895 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Verapamil eliminates the hierarchical nature of activation frequencies from the pulmonary veins to the atria during paroxysmal atrial fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Verapamil eliminates the hierarchical nature of activation frequencies from the pulmonary veins to the atria during paroxysmal atrial fibrillation
چکیده انگلیسی

BackgroundThere is evidence that verapamil promotes the persistence of paroxysmal atrial fibrillation (AF). Little is known about the underlying mechanisms.ObjectiveThe purpose of this study was to determine the effect of verapamil on dominant frequencies (DFs) in the pulmonary veins (PVs) and atria during paroxysmal AF with reference to its potential arrhythmogenicity.MethodsForty-three patients with paroxysmal AF were studied. Bipolar electrograms were recorded simultaneously during AF from the right atrial free wall (RAFW), coronary sinus (CS) and three PVs, or two PVs and the left atrial appendage (LAA). The DFs were obtained by fast Fourier transform analysis before and after infusion of verapamil (0.1 mg/kg, intravenously).ResultsAt baseline, the maximum DF among the PVs (6.9 ± 0.9 Hz) was significantly higher than the DF in the RAFW (6.2 ± 0.7 Hz), CS (5.7 ± 0.5 Hz), or LAA (5.9 ± 0.7 Hz) (P<.01); there was a substantial PV-to-atrial DF gradient (RAFW 0.7 ± 0.9, CS 1.1 ± 0.7, LAA 0.7 ± 0.9 Hz). Verapamil increased the atrial DF to 6.9 ± 0.8, 6.6 ± 0.7, and 7.2 ± 1.0 Hz in the RAFW, CS, and LAA, respectively (P<.0001) but did not affect the maximum PV DF (7.1 ± 0.7 Hz). The PV-to-atrial DF gradient was eliminated after verapamil (RAFW 0.2 ± 0.8, CS 0.5 ± 0.6, LAA −0.4 ± 0.8 Hz; P<.01 vs. baseline).ConclusionVerapamil increases the activation frequency in the atria but not in the PVs, eliminating the PV-to-atrial DF gradient during paroxysmal AF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 7, Issue 5, May 2010, Pages 577–583
نویسندگان
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