کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2925341 1175940 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vagal denervation and atrial fibrillation inducibility: Epicardial fat pad ablation does not have long-term effects
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Vagal denervation and atrial fibrillation inducibility: Epicardial fat pad ablation does not have long-term effects
چکیده انگلیسی

BackgroundMajor epicardial fat pads contain cardiac ganglionated plexi of the autonomic, predominantly vagal nerves. Vagal denervation may improve the success rate of atrial fibrillation (AF) treatment.ObjectivesThe purpose of this study was to elucidate the long-term effects of fat pad ablation on the electrophysiologic characteristics of the atrium and AF inducibility.MethodsSix mongrel dogs were studied. Cervical vagal stimulation was applied to determine effects on the sinus node, AV node, atrial effective refractory period (AERP), and AF inducibility. AERP and AF inducibility were evaluated at both the right atrial and left atrial appendages and at the right atrial and left atrial free walls. Radiofrequency energy was delivered epicardially to the entire areas of two major fat pads: right pulmonary vein fat pad and inferior vena cava-left atrium fat pad. Cervical vagal stimulation then was applied to confirm the acute effects of fat pad ablation. The same evaluation was repeated 4 weeks later.ResultsThe effects of vagal stimulation on the sinus node, AV node, and AERP were significantly eliminated immediately after fat pad ablation. However, these denervation effects disappeared after 4 weeks. At baseline, AF inducibility was increased by vagal stimulation (right atrial appendage: 72% ± 31% vs 4.8% ± 12%; right atrial free wall: 75% ± 31% vs 0.0% ± 0.0%; left atrial appendage: 60% ± 29% vs 0.0% ± 0.0%; left atrial free wall: 65% ± 42% vs 0.0% ± 0.0%). Fat pad ablation significantly reduced this vagal stimulation effect (8.3% ± 20%, 10% ± 22%, 17% ± 29%, and 25% ± 29%, respectively). However, similar to baseline, AF inducibility was strongly augmented by vagal stimulation 4 weeks after fat pad ablation (96% ± 10%, 100% ± 0.0%, 100% ± 0.0%, and 95% ± 11%, respectively).ConclusionRadiofrequency fat pad ablation may not achieve long-term suppression of AF induction in this canine model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 3, Issue 6, June 2006, Pages 701–708
نویسندگان
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