کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2925460 | 1175948 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Right ventricular pacing–induced electrophysiological remodeling in the human heart and its relationship to cardiac memory Right ventricular pacing–induced electrophysiological remodeling in the human heart and its relationship to cardiac memory](/preview/png/2925460.png)
BackgroundRight ventricular apical (RVA) pacing induces electrophysiological and structural remodeling. Cardiac memory (CM) evolves during the course of pacing and is readily apparent on electrocardiography (ECG) or vectorcardiography (VCG) when normal ventricular activation resumes.ObjectiveThis study sought to assess ventricular repolarization (VR) changes during pacing and intermittent normal ventricular conduction by ECG and VCG and to determine the temporal and conformational evolution of CM.MethodsTwenty sick sinus patients received a dual-chamber rate-adaptive (DDD-R) pacemaker and were paced from the RVA endocardium. The pacemakers were programmed to a short AV delay to maximize ventricular preexcitation. The ECG and VCG were recorded before and 1 day after implantation, and then daily for the first week (n = 6) or weekly for 5 to 8 weeks (n = 14), with the pacemakers temporarily programmed to AAI (normal ventricular activation).ResultsThe first parameters to change were T-vector amplitude, Tarea, and Tpeak-Tend (Tp-e), which decreased within 1 day after initiating pacing. CM became apparent between day 1 and day 3, was fully established after 1 week, and then remained stable. Signs of increased VR heterogeneity were observed as the T loop became more circular (decreased Tegenv) and distorted (increased Tavplan), which have previously been observed in conditions with increased risk for arrhythmias. Over weeks, VR duration was prolonged (increased QTc). In contrast, during ventricular pacing, a gradual shortening of the repolarization time was observed, suggesting a stabilizing adaptive process.ConclusionIn sick sinus syndrome patients in whom ventricular pacing is indicated, switching between normal AV conduction and ventricular pacing should be minimized to avoid periods of repolarization instability.
Journal: Heart Rhythm - Volume 4, Issue 12, December 2007, Pages 1477–1486