کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2926971 1575812 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
ترجمه فارسی عنوان
ناهنجاری های هدایت و آریتموژنز بطنی: نقش کانال های سدیم و اتصالات شکاف
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: IJC Heart & Vasculature - Volume 9, 7 December 2015, Pages 75–82
نویسندگان
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