کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2927058 1575815 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction
چکیده انگلیسی


• We measured native and MDA-collagen type IV IgM and IgG in MI patients and controls.
• Post-infarction patients had increased levels of IgM against native collagen type IV.
• Presence of IgG against native collagen type IV was associated with MI.
• In contrast, IgG against MDA-collagen type IV was decreased in MI patients.

BackgroundCollagen type IV is the major constituent of basement membranes underlying endothelial cells and is important for endothelial cell attachment and function. Autoantibodies against native collagen type IV have been found in various autoimmune diseases. Oxidation of LDL in the vascular wall results in the formation of reactive aldehydes, which could modify surrounding matrix proteins. Like oxidized LDL, these modified matrix proteins are likely to induce immune responses. We examined whether autoantibodies against native or aldehyde-modified collagen type IV are associated with myocardial infarction.MethodsIgM and IgG against native and aldehyde-modified collagen type IV were measured by ELISA in serum from 387 survivors of a first myocardial infarction and 387 age- and sex-matched controls.ResultsPost-infarction patients had significantly increased levels of IgM against native collagen type IV, and IgG against native collagen type IV was present at detectable level in 17% of patients as opposed to 7% of controls (p < 0.001). Controlling for major cardiovascular risk factors demonstrated that the presence of IgG against native collagen type IV was associated with myocardial infarction (OR 2.9 (1.6–5.4), p = 0.001). Similarly, subjects in the highest quartile of IgM against native collagen type IV had increased risk of having suffered myocardial infarction (OR 3.11 (1.8–5.4), p < 0.001) after adjusting for cardiovascular risk factors. In contrast, IgG against aldehyde-modified collagen type IV was decreased in myocardial infarction patients, but this association was not independent of established cardiovascular risk factors.ConclusionAutoantibodies against collagen type IV are associated with myocardial infarction independently of traditional cardiovascular risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: IJC Heart & Vasculature - Volume 6, 1 March 2015, Pages 42–47
نویسندگان
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