کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2928924 1576155 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Uric acid is an independent predictor of cardiovascular events in post-menopausal women
ترجمه فارسی عنوان
اسید اوریک یک پیش بینی مستقل از وقایع قلبی عروقی در زنان بعد از یائسگی است
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundUric acid (UA) is a risk factor for cardiovascular (CV) disease. In post-menopause UA levels are increased and strongly associated with subclinical organ damage. We investigated the prognostic significance of UA levels in predicting CV morbidity and mortality in post-menopausal women.MethodsWe considered 645 post-menopausal outpatients not taking hormone replacement therapy or any drugs interfering with UA levels. We evaluated major adverse cardiovascular events (MACE) as primary endpoint, with coronary, stroke or total events as secondary endpoint. Survival curves for tertiles of UA were obtained by using the Kaplan–Meier and Mantel methods. Effect of prognostic factors on survival was evaluated by multivariable Cox regression model, considering P < 0.05 as statistically significant.ResultsDuring a mean (SD) follow-up at 72.5 (23.5) months, there were 90 new CV events (2.31%): 62 coronary and 28 cerebrovascular events. The rate of nonfatal CV events (3.15% versus 2.03% and 1.52%, P = 0.009) as well as that of MACE (3.23% versus 2.11% and 1.59%, P = 0.011) were significantly higher in the third tertile than in the other two groups. Interestingly, cerebrovascular (1.15% versus 0.62% and 0.30%, P = 0.027) but not coronary events were significantly different among the three groups. In the Cox regression model, UA was independently and strongly associated with the incident risk of MACE (HR = 1.248, P = 0.001), cerebrovascular (HR = 1.657, P < 0.0001) and total events (HR = 1.391, P < 0.0001).ConclusionsIn post-menopause, independently of other CV risk factors and menopause duration, UA levels are associated with increased risk of death and MACE, in particular cerebrovascular but not coronary events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 197, 15 October 2015, Pages 271–275
نویسندگان
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