کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2929010 1576154 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice
ترجمه فارسی عنوان
یک رژیم غذایی با قند و چربی بالا عملکرد سیستولیک و دیاستولیک قلب را در موش ها آسیب می زند؟
کلمات کلیدی
رژیم غربی، رژیم غذایی با چربی بالا، رژیم غذایی با قند بالا، نارسایی قلبی کسر تخلیه را حفظ می کند، اختلال عملکرد دیاستولیک، چاقی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundHeart failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, exercise intolerance and cardiac dysfunction. Unhealthy diet has been associated with increased risk of obesity and heart disease, but whether it directly affects cardiac function, and promotes the development and progression of HF is unknown.MethodsWe fed 8-week old male or female CD-1 mice with a standard diet (SD) or a diet rich in saturated fat and sugar, resembling a “Western” diet (WD). Cardiac systolic and diastolic function was measured at baseline and 4 and 8 weeks by Doppler echocardiography, and left ventricular (LV) end-diastolic pressure (EDP) by cardiac catheterization prior to sacrifice. An additional group of mice received WD for 4 weeks followed by SD (wash-out) for 8 weeks.ResultsWD-fed mice experienced a significant decreased in LV ejection fraction (LVEF), reflecting impaired systolic function, and a significant increase in isovolumetric relaxation time (IRT), myocardial performance index (MPI), and LVEDP, showing impaired diastolic function, without any sex-related differences. Switching to a SD after 4 weeks of WD partially reversed the cardiac systolic and diastolic dysfunction.ConclusionsA diet rich in saturated fat and sugars (WD) impairs cardiac systolic and diastolic function in the mouse. Further studies are required to define the mechanism through which diet affects cardiac function, and whether dietary interventions can be used in patients with, or at risk for, HF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 198, 1 November 2015, Pages 66–69
نویسندگان
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