کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2930074 1576238 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A spontaneous, double-blind, double-dummy cross-over study on the effects of daily vardenafil on arterial stiffness in patients with vasculogenic erectile dysfunction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
A spontaneous, double-blind, double-dummy cross-over study on the effects of daily vardenafil on arterial stiffness in patients with vasculogenic erectile dysfunction
چکیده انگلیسی

BackgroundIt is known that the incidence of endothelial dysfunction in patients with vascular erectile dysfunction (ED) is increased. The effects of daily vardenafil on endothelial function and arterial stiffness in patients with erectile dysfunction (ED) have never been investigated.Methods20 men complaining vascular ED (mean IIEF5 = 12 ± 6 and peak systolic velocity-PSV = 24 ± 2 cm/s) were enrolled in a 4-week, randomized, double-blind, double-dummy, crossover study (mean age 59 ± 11) and received either vardenafil 10 mg daily or 20 mg on-demand with a two-week washout interval. Primary endpoints were variation from baseline of reactive hyperemia (RH) and augmentation index (AI) calculated by fingertip peripheral arterial tonometry (PAT) device. Secondary endpoints were variations of IIEF-5 and SEP3 scores from baseline and plasma surrogate markers of endothelial function, i.e. endothelin-1 (ET-1) and adrenomedullin (ADM).ResultsPatients who took daily vardenafil (vs. on-demand) reported significant (P < 0.01) improvements in arterial stiffness as evaluated by AI and reduction of plasma ADM levels (p < 0.05) but no improvement in average RH. When corrected for heart rate, ADM showed a strong direct relationship with AI (r2 = 0.22; p < 0.005). The proportion of patients with an IIEF5 score of ≥ 22 or in SEP3 percentage of success rates were similar. Each treatment resulted in significantly greater IIEF5 scores (p < 0.001) and better SEP3 response rates (p < 0.0001) compared with baseline.ConclusionsWe demonstrated that daily vardenafil improves arterial stiffness and erectile function measurements in men with severe vasculogenic ED. This effect may be mediated, at least in part, by a reduction in ADM circulating levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 160, Issue 3, 18 October 2012, Pages 187–191
نویسندگان
, , , , , ,