کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2932288 1576304 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of high-density lipoprotein cholesterol level in patients with variant angina pectoris
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Impact of high-density lipoprotein cholesterol level in patients with variant angina pectoris
چکیده انگلیسی

BackgroundIt is generally considered that patients with variant angina pectoris (VAP) have a potential disturbance in the coronary endothelium. High-density lipoprotein (HDL) has been shown to mediate vasodilation as a result of its endothelium-enhancing property; however, the significance of low HDL in patients with VAP has not been clarified. We sought to determine the association between a low level of high-density lipoprotein cholesterol (HDL-C) and VAP.MethodsWe examined a total of 174 consecutive patients who were suspected of having VAP and underwent spasm provocation test by direct injection of acetylcholine into the coronary arteries. One hundred and three patients (59%) were consequently diagnosed as having VAP. Serum HDL-C, fasting plasma glucose (FPG), and glycohemoglobin levels were measured in all patients.ResultsHDL-C in quartiles showed a significant negative correlation with the presence of VAP. Multivariate analysis revealed that the lowest HDL-C quartile (< 43 mg/dl), as well as cigarette smoking and impaired fasting glucose/diabetes mellitus, was an independent determinant of VAP (odds ratio = 3.39, P = 0.010). Patients in the highest FPG quartile (≥ 106 mg/dl) or with cigarette smoking habit in combination with the lowest HDL-C quartile showed an increased risk for VAP (relative risk = 2.01 and 1.88, respectively).ConclusionsA low level of HDL-C is an independent determinant for VAP. Endothelial dysfunction caused by a low HDL state may play a role in the development of VAP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 140, Issue 2, 15 April 2010, Pages 175–181
نویسندگان
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