Low adiponectin levels predict late in-stent restenosis after bare metal stenting in native coronary arteries

BackgroundAdiponectin, the most abundant protein secreted from adipose tissue, possesses anti-atherogenic properties. This study tested whether adiponectin plasma levels predict in-stent restenosis (ISR) after successful percutaneous coronary intervention (PCI) with bare-metal stents.MethodsThe study included 148 consecutive patients who had elective PCI with bare-metal stents in de novo lesions of native coronary arteries for symptomatic coronary artery disease. Adiponectin levels were measured by ELISA 3 days or less before PCI.ResultsAngiographic ISR (defined as > 50% diameter stenosis) was found in 49 (33%) patients during 6 months of the follow-up. Adiponectin levels were lower in patients with ISR than those without ISR (3.5 ± 0.3 vs. 6.9 ± 0.4 μg/ml, respectively, p < 0.01). Adiponectin levels were inversely correlated with late luminal loss of the stented lesions (r = − 0.40, p < 0.01). Using multivariate logistic regression analysis, low adiponectin levels (< 4.5 μg/ml, arbitrarily determined from a receiver operating characteristic curve) served as a predictor of ISR that was independent of angiographic and procedural variables, and clinical factors known to be associated with ISR (odds ratio, 7.9; 95% CI, 3.0–21; p < 0.01). Furthermore, low adiponectin levels also independently predicted target lesion revascularization (n = 35) during follow-up (odds ratio, 3.7; 95% CI, 1.4–9.7; p < 0.01).ConclusionsLow adiponectin levels have a predictive value for late ISR after PCI with bare-metal stents in native coronary arteries.