Effects of angiotensin II and angiotensin II type 1 receptor blockade on neointimal formation after stent implantation

Supraphysiological levels of angiotensin II aggravates neointimal formation in the stented rat abdominal aorta, and in parallel decreases endothelial function. AT1-receptor blockade does not reduce neointimal formation in rats without supraphysiological angiotensin II levels.