کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2934460 1576347 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
چکیده انگلیسی

BackgroundThe present study was conducted to investigate the relation between the accumulation of the risk factors of thromboembolism and the levels of hemostatic markers in patients with nonvalvular atrial fibrillation (NVAF).MethodsFive hundred ninety-one NVAF patients and 129 control subjects were categorized into low, moderate or high risk of thromboembolism, according to CHADS2 index. One point each was given to patients with advanced age (≥ 75 years), hypertension, congestive heart failure, and diabetes mellitus, and 2 points, to those with prior ischemic stroke or transient ischemic attack. Patients with CHADS2 score of 0, 1 or 2, and ≥ 3 were classified as low, moderate and high risk, respectively. Levels of hemostatic markers (platelet factor 4, β-thromboglobulin, prothrombin fragment F1 + 2 and D-dimer) were determined.ResultsOf 591 patients with NVAF, 302 were treated with warfarin (mean international normalized ratio 1.88). D-dimer levels increased as the risk level increased irrespective of warfarin use. Particularly, NVAF patients without receiving warfarin (n = 289) had significantly higher D-dimer levels than control patients (e.g., for high risk patients, 175 ± 144 vs 75 ± 87 ng/ml, p < 0.001), while NVAF patients receiving warfarin had intermediate levels (136 ± 156 ng/ml). F1 + 2 levels increased as the risk level increased, and were significantly suppressed by warfarin. Levels of markers of platelet activation (platelet factor 4 and β-thromboglobulin) were increased in NVAF patients but not affected by the risk level.ConclusionCoagulation and fibrinolytic activity is increased along with the accumulation of the risk factors of thromboembolism in NVAF patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 126, Issue 3, 6 June 2008, Pages 316–321
نویسندگان
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