Nuclear factor-kappaB activity in peripheral blood mononuclear cells in cachectic and non-cachectic patients with chronic heart failure

The activity of NF-κB system in peripheral immune cells is augmented in patients with advanced CHF, whereas it is diminished in those with cardiac cachexia. The significance of derangements within NF-κB system in PBMC for immune phenomena seen in cachectic and non-cachectic CHF patients remains further studies.