کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2935984 1576389 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beneficial effects of nifedipine on vasodilator response to acetylcholine in coronary and brachial arteries in the patients with coronary artery disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Beneficial effects of nifedipine on vasodilator response to acetylcholine in coronary and brachial arteries in the patients with coronary artery disease
چکیده انگلیسی

BackgroundNifedipine has been reported to improve endothelial function. However, there are few simultaneous studies on the effects of nifedipine on coronary and peripheral endothelial function in humans.MethodsTo investigate the effects of nifedipine on endothelial function in coronary artery (CA) and brachial artery (BA) in coronary artery disease (CAD), we measured vasodilator responses of CA and BA to acetylcholine (ACh, endothelium-dependent dilation) in 13 patients (63 ± 10 years old) with CAD before and after sublingual administration of nifedipine 10 mg. To measure blood flow, a Doppler guidewire was inserted into the major branch of CA and the left BA. ACh was infused at 10− 7 mol/l for 3 min into CA and at 15.0 μg/ml for 5 min into BA, respectively. The vasodilator response to ACh was assessed by the ratio of ACh-induced flow / baseline flow (CAVR index, the ratio of CA flow changed by ACh; BAVR index, the ratio of BA flow changed by ACh).ResultsNifedipine significantly increased both the CAVR and BAVR index : CAVR index, from 1.33 ± 0.54 to 1.76 ± 0.52 (32%) and BAVR index, from 1.74 ± 0.83 to 2.18 ± 0.93 (25%), respectively, p < 0.05. In addition, nifedipine-induced changes in CAVR tended to correlate with those of BAVR (r = 0.42. p = 0.06).ConclusionsAcute administration of nifedipine improves both coronary and brachial artery vasodilator responses to ACh. Nifedipine improves coronary and peripheral endothelial function in patients with CAD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 113, Issue 3, 18 November 2006, Pages 305–310
نویسندگان
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