کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2936109 | 1576380 | 2007 | 9 صفحه PDF | دانلود رایگان |
l-Arginine is the substrate of endothelial nitric oxide synthase (eNOS) and the main precursor of nitric oxide (NO) in the vascular endothelium. l-Arginine improves endothelial function in patients with hypercholesterolemia, hypertension and smokers, while its role in diabetes remains unclear. Oral supplementation of l-arginine leads to a significant improvement of endothelium-dependent forearm vasodilation in hypercholesterolemic patients, while intravenous infusion of l-arginine improves endothelial function in healthy smokers. l-Arginine has anti-hypertensive properties, although its effects on endothelial function in hypertensive patients needs further evaluation. In conclusion, l-arginine administration may be useful in patients with premature atherosclerosis.
Journal: International Journal of Cardiology - Volume 116, Issue 3, 4 April 2007, Pages 300–308