کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2936163 1576407 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Seasonal variation of C-reactive protein in apparently healthy Koreans
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Seasonal variation of C-reactive protein in apparently healthy Koreans
چکیده انگلیسی

BackgroundC-reactive protein (CRP) is known as an emerging recognized marker of the potential risk of myocardial infarction and stroke, and several studies have reported higher incidences of cardiovascular events during the winter months. Here, we investigated seasonal CRP variations using a high-sensitivity immunoradiometric assay in apparently healthy Koreans.MethodsThis study included 18,445 apparently healthy Koreans (12,064 men and 6381 women, 47.2 (11.5) years of age). Anthropometric indices of adiposity, metabolic variables, blood pressure (BP), and several cardiovascular risk factors were measured. High sensitivity CRP testing was performed by immunonephelometry.ResultsThe mean (SD) CRP level in the study population was 1.66 (2.15) mg/L, and mean (SD) CRP levels in the spring, summer, fall and winter were 1.76 (2.30) mg/L, 1.51 (1.94) mg/L, 1.61 (2.08) mg/L, and 1.76 (2.30) mg/L, respectively. After adjusting for age, sex, diabetes, hypertension, regular exercise, smoking, and body mass index, the odds ratios of an elevated CRP in the spring, fall and winter season were 1.196 (95% CI, 1.024–1.396 p = 0.024), 1.086 (95% CI, 0.943–1.250 p = 0.251) and 1.258 (95% CI, 1.088–1.456 p = 0.002), respectively, as compared with the summer season.ConclusionsOur results indicate a highly significant seasonal variation in CRP levels, with higher values during winter and spring than in summer. Elevated plasma CRP levels can be related to an increased risk of cardiovascular events, which are more prominent during the winter months. To further elucidate this relationship additional studies are needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 107, Issue 3, 8 March 2006, Pages 338–342
نویسندگان
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