کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2956990 1578082 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An evaluation of the efficacy of olmesartan medoxomil in Black patients with hypertension
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
An evaluation of the efficacy of olmesartan medoxomil in Black patients with hypertension
چکیده انگلیسی

Blacks appear to have a more modest blood pressure (BP) response to angiotensin receptor blocker (ARB) monotherapy than non-Blacks. This post-hoc analysis compared the BP-lowering efficacy of olmesartan medoxomil (OM), losartan potassium (LOS), and valsartan (VAL) in Black versus non-Black participants in a randomized, forced-titration study. Patients were randomized to OM 20, LOS 50, and VAL 80 mg/day or placebo for 4 weeks and uptitrated to 40, 100, and 320 mg/day doses, respectively, by study end. The primary end point was the mean change from baseline in diastolic BP (DBP) at week 8. All treatments produced significant reductions in mean DBP and systolic BP (SBP) in Blacks (n = 150; P < .001). BP <140/90 mm Hg was achieved in 35.0%, 15.6%, 29.7%, and 5.0% of Blacks receiving OM, LOS, VAL, and placebo, respectively, and in 41.0%, 21.1%, 28.8%, and 14.5% of non-Blacks receiving OM, LOS, VAL, and placebo, respectively, after 8 weeks. BP-lowering efficacy of the three agents was similar at 3 months. OM had the greatest early efficacy, with numerically greater mean reductions in DBP and SBP, and a higher proportion of Black and non-Black patients achieving goal BP of 140/90 mm Hg at week 8.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 3, Issue 6, November–December 2009, Pages 395–402
نویسندگان
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