کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2957004 1578041 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress
ترجمه فارسی عنوان
اثرات افتراق نابوولول و متپرولول بر سختی شریان، سلول های پیش داوری و استرس اکسیداتیو
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی


• Beta–blocker therapy is associated with an increase in circulating progenitor cells
• Nebivolol did not improve aminothiol markers of oxidative stress
• Nebivolol improved arterial stiffness only in beta–blocker naïve subjects

Unlike traditional beta receptor antagonists, nebivolol activates nitric oxide. We hypothesized that therapy with nebivolol compared with metoprolol would improve arterial stiffness, increase levels of circulating progenitor cells (PC), and decrease oxidative stress (OS). In a randomized, double–blind, cross–over study, 30 hypertensive subjects received either once daily nebivolol or metoprolol succinate for 3 months each. Pulse wave velocity and augmentation index were measured using tonometry. Flow cytometry was used to measure circulating PC. OS was measured as plasma aminothiols. Measurements were performed at baseline, and repeated at 3 and 6 months. No significant differences were present between the levels of OS, arterial stiffness, and PC numbers during treatment with metoprolol compared with nebivolol. In subgroup analyses of beta–blocker naïve subjects (n = 19), nebivolol reduced pulse wave velocity significantly compared with metoprolol (−1.4 ± 1.9 vs. −0.1 ± 2.2; P = .005). Both nebivolol and metoprolol increased circulating levels of CD34+/CD133 + PC similarly (P = .05), suggesting improved regenerative capacity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 9, Issue 3, March 2015, Pages 206–213
نویسندگان
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