Incorporating human leukocyte antibody results into clinical practice

The use of human leukocyte antigen (HLA) antibody testing by solid-phase assay has improved both the specificity and sensitivity of HLA antibody detection. It did, however, introduce questions regarding interpretation of crossmatch results in light of these additional data. Herein we provide a clinician's and a laboratory professional's perspective on incorporating HLA results into clinical practice. We strongly encourage fostering ongoing dialog between the two disciplines to develop appropriate, specific guidelines.