The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion

In donation after cardiac death lungs, perfusate ET-1 and Big ET-1 are potential predictors of lung function during EVLP and after lung transplantation. They were also associated with non-use of lungs after EVLP and thus could represent useful biomarkers to improve the accuracy of donor lungs selection.