کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2971660 | 1578288 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetic drug-drug interactions between calcineurin inhibitors and proliferation signal inhibitors with anti-microbial agents: Implications for therapeutic drug monitoring
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Infections account for 15% to 20% of deaths in transplant recipients; thus, rapid and appropriate therapeutic intervention is required. However, many anti-microbial agents can interact significantly with a transplant recipient's immunosuppressive regimen, placing them at risk for a potential adverse drug reaction and prolonged hospitalization. This investigation highlights the pharmacokinetic drug-drug interactions between the calcineurin inhibitors and proliferation signal inhibitors with commonly used anti-microbial agents, specifically addressing mechanism, management, onset of action, magnitude of effect and strength of evidence for each interaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Heart and Lung Transplantation - Volume 30, Issue 2, February 2011, Pages 124-135
Journal: The Journal of Heart and Lung Transplantation - Volume 30, Issue 2, February 2011, Pages 124-135
نویسندگان
Robert L. PharmD, MSPH, Scott W. PharmD, Marilyn E. MD, JoAnn MD,