Vascular Endothelial Growth Factor Increases Human Cardiac Microvascular Endothelial Cell Permeability to Low-Density Lipoproteins

These results demonstrate that VEGF increases low-density lipoprotein permeability through endothelial monolayers, and this effect is correlated with VEGF-induced disruption of endothelial tight junctions resulting in the formation of intercellular gaps.