Anti-LFA-1 Monotherapy Prevents Neointimal Formation in a Murine Model of Transplant Intimal Hyperplasia

We have demonstrated for the first time that LFA-1α blockade on its own can prevent development of TIH in an experimental model. The concept of modulating LFA-1α-mediated leukocyte migration and T-cell activation may therefore be of relevance to clinical cardiac transplantation and, as such, represents a potential target for therapeutic intervention against clinical CAV.