Improved Myocardial Function After Cold Storage With Preservation Solution Supplemented With a Carbon Monoxide-Releasing Molecule (CORM-3)

The improved functional recovery and reduced enzyme release after cardiac cold storage with CORM-3, but not iCORM-3, indicate that CO is the main mediator of myocardial protection. Thus, CO-RMs can be used as adjuvants to improve the preservation of hearts for transplantation.