Sirolimus-Based Immunosuppression After Cardiac Transplantation: Predictors of Recovery From Calcineurin Inhibitor-Induced Renal Dysfunction

Treatment with sirolimus facilitates CNI lowering or discontinuation associated with a significant improvement in renal function after 1 month. Better renal function 3 months before conversion and a shorter time from transplant to conversion were associated with a greater improvement in renal function after conversion to sirolimus.