Multiple Human Mesenteric Arterial Grafts From the Same Donor to Study Human Chronic Vascular Rejection in Humanized SCID/Beige Mice

We show that it is feasible to graft multiple human arteries from the same donor into SCID/beige mice, and that a specific and typical CVR is observed after reconstitution with allogeneic spleen cells. Our method allows for pre-clinical testing of new therapeutics in controlled series.