Cardiomyocyte Bridging Between Hearts and Bioengineered Myocardial Tissues With Mesenchymal Transition of Mesothelial Cells

The direct attachment of layered cardiomyocyte sheets on the heart surface promotes mesothelial cell transdifferentiation and cardiomyocyte bridging, leading to functional communication via gap junctions. These results indicate that these bioengineered myocardial tissues may improve damaged heart function via synchronized beating.