Brain Natriuretic Peptide is Produced Both by Cardiomyocytes and Cells Infiltrating the Heart in Patients with Severe Heart Failure Supported by a Left Ventricular Assist Device

The significant decrease in serum BNP concentration after LVAD support coincides with a decrease in BNP mRNA and protein expression in the heart. BNP is produced in the left ventricle not only by cardiomyocytes but also by endothelial cells, T cells, and macrophages. Unloading of the left ventricle by a LVAD results in decreased BNP expression in the heart and plasma and may play an important role in the reverse remodeling process of the heart.