The Effect of Anti-inflammatory Properties of Mycophenolate Mofetil on the Development of Lung Reperfusion Injury

MMF limits lung ischemia-reperfusion-induced increases in vascular permeability and inflammatory cell sequestration in lung parenchyma and alveolar spaces. The protection is mediated at the transcriptional level via an attenuation of early EGR-1 and AP-1 transactivation, which was found to be associated with reduced late MCP-1 and CINC protein secretion. The use of MMF in concert with an agent that affects NF-κB activation may provide even further protection against lung reperfusion injury as multiple inflammatory pathways are inhibited.