Role of glucose-insulin-potassium regimen in non-ST elevation myocardial infarction/unstable angina

This study was conducted on patients who presented to the cardiology department and were admitted either in cardiology ward or coronary care unit of Sir Sunder Lal Hospital, BHU, Varanasi with a diagnosis of acute coronary syndrome (ACS). Ninety three patients were enrolled in the study. The study period extended from January 2006 to March 2007.Study was a hospital based prospective study that involved estimation of the clinical, echocardiographic features and survival status of patients who presented with ACS, with or without GIK regimen.Based on clinical grounds and electrocardiographic findings patients were enrolled: NSTEMI/unstable angina.The 30 days mortality was 4 of 47 (8.5%) patients receiving GIK compared with 8 of 46 (17%) patients in control group (relative risk [RR], 0.45, 95%; confidence interval [CI] 0.12-1.62). In 85 patients (94.4) without signs of heart failure (Killip class I) 30 days mortalitywas 2 of 42 patients (4.7%) in GIK group vs. 5 of 43 patients (11.67%) in control group (RR 0.38, 95%; CI 0.06-2.07). In 8 (5.6%) patients with signs of HF (Killip class ≥ II), 30 days mortality was 2 of 5 patients (40%) in GIK group vs. 3 of 3 (100%) in control group.In patients with non-ST elevation myocardial infarction (NSTEMI)/ unstable angina, 30 days mortality was significantly lower in GIK group as compared to control group and in patients without signs of heart failure (Killip class I) 30 days mortality was significantly lower as compared to patients with signs of heart failure (Killip class ≥ II).