کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2976394 | 1179382 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
L'hypertension artérielle est-elle une maladie de la microcirculation ?
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Capillary and arterioles rarefaction has been reported in animal models of hypertension and in essential and borderline hypertension. Moreover, young adults with a predisposition to hypertension may exhibit microvascular rarefaction suggesting that defective angiogenesis-arteriogenesis may be an etiological component of high blood pressure. Nevertheless, in other studies, VEGF plasma levels are increased in hypertensive subjects and low birth weight predicts higher blood pressure but not dermal capillary density. In fibrin gel chambers implanted in rats, angiogenesis-arteriogenesis are increased in spontaneously hypertensive rats (SHR) compared to their controls. In parallel, fibroblast growth factor synthesis is significantly increased in SHR fibrin gel chambers. Thus, excess in angio/arteriogenic factors synthesis could stimulate neovascularisation including resistive arterioles formation, which in turn increase peripheral vascular resistance and consequently trigger the hypertensive mechanism itself.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal des Maladies Vasculaires - Volume 32, Issue 3, July 2007, Pages 131-134
Journal: Journal des Maladies Vasculaires - Volume 32, Issue 3, July 2007, Pages 131-134
نویسندگان
D. Stephan,