کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2985814 1578676 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Survival according to the site of bronchial microscopic residual disease after lung resection for non–small cell lung cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Survival according to the site of bronchial microscopic residual disease after lung resection for non–small cell lung cancer
چکیده انگلیسی

ObjectiveWe performed a retrospective study evaluating the effect on survival of different sites of microscopic residual disease at the bronchial resection margin after surgical intervention for non–small cell lung cancer.MethodsSurvival of patients with different sites of residual disease was compared with survival of patients with curative resections, taking the pathologic TNM stage of the tumor into consideration.ResultsThere was a trend for patients with stage I and II non–small cell lung cancer with residual disease limited to the epithelium and with peribronchial invasion to behave like patients with complete resections (61% and 41% five-year survival for stage I and II disease, respectively). This contrasts with patients with submucosal invasion and lymphatic infiltration, among whom there were no survivors at 5 years. There was no difference in survival between curative resections and residual disease of any type when the tumor was stage III or IV.ConclusionsIn patients with stage I and II disease, when residual disease consists of submucosal invasion or lymphatic infiltration, specific and aggressive treatments to clear residual margins might be contemplated because of their possible adverse effect on survival. This contrasts with patients with stage III and IV disease, in whom survival is more related to the stage of the primary tumor than to residual disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Thoracic and Cardiovascular Surgery - Volume 137, Issue 3, March 2009, Pages 622–626
نویسندگان
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