Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta

The elastase-induced mouse model of abdominal aortic aneurysm (AAA) has been widely accepted because of its pathologic similarities to human AAAs. In this study, we aimed to develop a permutation of this model to explore how particular cell types and molecular signaling pathways contribute to AAA. Using an orthotopic allograft transplantation model, we provide a method to elucidate etiopathogenetic mechanisms of AAA formation and to explore new therapeutic possibilities.